Publications | amszpilmangroup

47. Solar Light Assisted C-H Activation and C-C coupling of hindered N,N-Dimethyl-Anilines with Activated Methylene Compounds

Sourav Santra, Jonatan Rahamim, Ortal Dorfman, Abhijit Kashid, Galit Parvari*, Yoav Eichen, and Alex M. Szpilman*

Synthesis, 2025, Accepted for publication

46. Unified Strategy for the α-Functionalization of Esters, Imides, and Ketones via Enolonium Species

Raja Kapanaiah, Bat-El Oded, Raz Strugano Asit Ghosh, Subrata Maity Natalia Fridman, and Alex M. Szpilman*

Cell Reports Physical Science, 2025, 6, 1102460.

45. Catalytic Atroposelective Aerobic Oxidation Approaches to Axially Chiral Molecules

Lenin K. Verdhi, Asit Ghosh, Natalia Fridman, and Alex M. Szpilman*

The Journal of Organic Chemistry, 2023, 88, 8413–8430.

44. 2-Fluoro Enones via an Umpolung Moirta-Baylis-Hilman Reaction of Enones

Subrata Maity and Alex M. Szpilman*

Organic Letters, 2023, 25, 1218-1222

43.2-Nitro-cyclopropyl-1-carbonyl Compounds from Unsaturated Carbonyl Compounds and Nitromethane via Enolonium Species

Asit Ghosh Yuriy B. Lipisa, Natalia Fridman, and Alex M. Szpilman*

The Journal of Organic Chemistry, 2023, 88, 1977-1987

42. Copper and Chiral Nitroxide Catalyzed Oxidative Kinetic Resolution of Axially Chiral N-Arylpyrroles

Lenin Kumar Verdhi, Natalia Fridman, and Alex M. Szpilman*

Organic Letters, 2022, 24, 5078-5083

41. Imidazolium Based Energetic Materials

Sagi Sevilia, Galit Parvari, Jonathan Bernstein, Natalia Fridman, Dan Grinstein, Levi Gottlieb, Yoav Eichen* and Alex M. Szpilman*

ChemistrySelect, 2022, 7, e202200322

40. Synthesis and Reactions of Borazines

Ishita Neogi* and Alex M. Szpilman*

Synthesis, 2022, 54, 1877-1907

Featured on the Front Cover page of Issue 8

39. Solar and Visible Light Assisted Peptide Synthesis

Abhaya K. Mishra, Galit Parvari, Sourav K. Santra, Andrii Bazylevich Ortal Dorfman, Jonatan Rahamim, Yoav Eichen,* and Alex M. Szpilman*

Angewandte Chemie International Edition, 2021, 60, 12406-12412

Selected a HOT paper, Featured on the Inside Cover

Highlighted in Synform and Synfact of the Month for November 2021

38. Visible-Spectrum Solar-Light-Mediated Benzylic C–H Oxygenation Using 9,10-Dibromoanthracene As an Initiator

Sourav K. Santra, and Alex M. Szpilman*

The Journal of Organic Chemistry, 2021, 86, 1164-1171

37. The Application of Nitroxides in Organic Synthesis

Lenin Kumar Verdhi and Alex M. Szpilman*

Book Chapter in Nitroxides: Synthesis, Properties, and Applications, 2021, Royal Society of Chemistry

36. Direct Umpolung Morita‐Baylis‐Hillman like α‐Functionalization of Enones

via Enolonium Species

Shlomy Arava, Sourav K. Santra, Gulab K. Pathe, Raja, Kapanaiah, and Alex M. Szpilman*

Angewandte Chemie International Edition, 2020, 59, 15171-15175

Selected a HOT paper

35. Indium(III) Catalyzed Reactions of Vinyl Azides and Indoles

Atul A. More and Alex M. Szpilman*

Organic Letters, 2020, 10, 3759–3764

34. Azido-Enolonium Species in C–C and C–N Bond-Forming Coupling Reactions

Atul A. More, Sourav K. Santra and Alex M. Szpilman*

Organic Letters, 2020, 22, 768-771

33. First α-Deuterium Nitroxides; Synthesis and EPR Study

Hila Toledo, Boris L. Tumanski,* Denis S. Sabirov, Alexander Kaushansky, Natalia Fridman, and Alex M. Szpilman*

Organic and Biomolecular Chemistry, 2019, 17, 7000-7006

32. Amine-tetrachloromethane charge transfer complexes: a structural and computational study

Abhaya K. Mishra, Galit Parvari, Irit Cohen, Natalie Fridman, Yoav Eichen, and Alex M. Szpilman*

Journal of Coordination Chemistry, 2018, 71, 2082-2089

31. A Two-step Protocol for Umpolung Functionalization of Ketones via Enolonium Species

Shlomy Arava, Shimon Maksymenko, Keshaba N. Parida, Atul A. More, Gulab K. Pathe,Yuriy B. Lipisa and Alex M. Szpilman*

Journal of Visualized Experiments 2018, (138), e57916

30. Cross-Coupling of Dissimilar Ketone Enolates via Enolonium Species to afford Non-symmetrical 1,4-Diketones

Keshaba N. Parida, Shimon Maksymenko, Gulab K. Pathe, and Alex M. Szpilman*

Beilstein Journal of Organic Chemistry, 2018, 14, 992–997 (Special Issue on Hypervalent iodine in Synthesis)

29. α-N-Heteroarylation and α-Azidation of Ketones via Enolonium Species

Atul A. More, Gulab K. Pathe, Keshaba N. Parida,Shimon Maksymenko, Yuriy B. Lipisa and Alex M. Szpilman*

The Journal of Organic Chemistry, 2018, 83, 2442–2447

28. Transition Metal-Free Intermolecular Arylation of Ketones via Enolonium Species

Shimon Maksymenko, Keshaba N. Parida, Gulab K. Pathe, Atul A. More, Yuriy B. Lipisa and Alex M. Szpilman*

Organic Letters, 2017, 19, 6312-6315

27. Solar Assisted Direct Amidation via a Charge-Transfer Complex

Irit Cohen, Abhay K. Mishra, Galit Parvari, Rachel Edrei, Mauricio Dantus, Yoav Eichen, and Alex M. Szpilman*

Chemical Communications, 2017, 53, 10128-10131

26. Enolonium Species – Umpoled Enolates

Shlomy Arava, Jayprakash N. Kumar, Shimon Maksymenko, Mark A. Iron, Keshaba N. Parida, and Alex M. Szpilman*

Angewandte Chemie International Edition, 2017, 56, 2599-2603

25. Mechanism of the Copper/TEMPO Catalyzed Aerobic Oxidation of Alcohols

Mark A. Iron and Alex M. Szpilman*

Chemistry a European Journal, 2017, 23, 1368-1378

Selected a HOT paper

Highlighted in ChemistryViews

24. Novel water-soluble amphotericin B-PEG conjugates with reduced low toxicity and potent in vivo efficacy

Asaf Halperin, Yana Shadkchan, Evgeni Pisarevsky, Alex M. Szpilman,* Hannah Sandovsky, Nir Osherov,* Itai Benhar*

Journal of Medicinal Chemistry, 2016, 59, 1197-1206

23. Synthesis and Stability of α-Hydrogen Nitroxides

Hila Toledo, Michal Amar, Sukanta Bar, Mark A. Iron, Boris Tumanskii, Natalia Fridman, Linda J. W. Shimon, Mark Botoshansky, and Alex M. Szpilman*

Organic & Biomolecular Chemistry, 2015, 13, 10726 - 10733

Selected a HOT paper by the reviewers

22. Catalytic Activity of Recoverable IAPNO α-Hydrogen Nitroxyl Radicals in the Aerobic Oxidation of Alcohols

Sukanta Bar, Jayprakash N. Kumar, Michal Amar, Hila Toledo, Rami J. Batrice and Alex M. Szpilman*

ChemCatChem 2015, 7, 1129-1135.

Highlighted in ChemInform

21. Design Concept for α-Hydrogen Substituted Nitroxyl Radicals

Michal Amar, Sukanta Bar, Mark A. Iron, Hila Toledo, Boris Tumanskii, Linda J. W. Shimon, Mark Botoshansky, Natalia Fridman and Alex M. Szpilman*

Nature Communications, 2015, 6, 6070

For the Technion's Press release in English see Click Here
For the Technion's Press release in Hebrew see Click Here
To read coverage of our work in the Jerusalem Post see Here

For coverage of our work at diplomacy.co.il Click Here
For coverage of our work in the Hebrew language media Click Here, Here, Here, Here, and Here

20. Oxidative Asymmetric Umpolung Alkylation of Evans’ β-Keto Imides by Dialkylzinc

Tom Targel, Jayprakash N. Kumar, O. Svetlana Shneider, Sukanta Bar, Natalia Fridman, Shimon Maximenko, and Alex M. Szpilman*

Organic & Biomolecular Chemistry 2015, 13, 2546-2549

Chosen as a HOT paper by the reviewers

Highlighted in ChemInform

19. Oxidative Umpolung α-Alkylation of Carbonyl Compounds

O. Svetlana Shneider, Evgeni Pisarevsky, Peter Fristrup and Alex M. Szpilman*

Organic Letters 2015, 17, 282-285

One of the most downloaded Organic Letters of January 2015 (>1000 downloads).

Highlighted in: Paul Knochel, Jeffrey M. Hammann Synfacts 2015, 11, 303.

and in ChemInform

Choosen as TCI-Chemicals “Paper of the Week” for 25. May to 1 June 2015

18. Synthesis of Axially Chiral 1,8-Diarylnapthalene Ligands and Application in Asymmetric Catalysis - An Intriguing Fluorine Effect

Harisadhan Ghosh, Ravishashidhar Vavilala and Alex M. Szpilman*

Tetrahedron; Asymmetry, 2015, 26, 79-84

This article was one of the most downloaded papers from the Journal during February to May 2015

17. Synthetic and Mechanistic study of the Catalytic Enantioselective Synthesis of primary β-Amino Ketones from Enones and a Fluorinated Gabriel Reagent

Shlomit Avidan-Shlomovich, Harisadhan Ghosh and Alex M. Szpilman*

ACS Catalysis, 2015, 5, 336-342

16. Organometallic Complexes of Vanadium

Orel S. Shneider and Alex M. Szpilman*

Science of Synthesis, 2014, Knowledge Updates vol. 2¸139-165.

15. Organocatalytic Oxidation of Aldehydes to Mixed Anhydrides

Hila Toledo, Evgeni Pisarevsky, Adi Abramovich and Alex M. Szpilman*

Chemical Communications, 2013, 49, 4367-4369

Selected for inclusion in the 2013 Young Investigator issue

Highlighted in: ChemInform

14. Organocatalytic Oxidative Dimerization of Alcohols to Esters

Adi Abramovich, Hila Toledo, Evgeni Pisarevsky and Alex M. Szpilman*

Synlett, 2012, 23, 2261-2265

Highlighted in: ChemInform

13. Cycloadditions (Bookchapter)

Alex M. Szpilman* and Erick M. Carreira* in Silver in Organic Synthesis Ed. Michael Harmata, Wiley, 41 pages 2010

This book was given an honor able mention for the 2010 Prose Awards

The chapter was highlighted in: ChemInform

12. Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

Alex M. Szpilman* and Erick M. Carreira*

Angewandte Chemie International Edition, 2010, 49, 9592–9628 (Contributed review)

Highlighted in: ChemInform and ChemistryViews

Patents

3. “Amphotericin B Derivatives”

Alex M. Szpilman, Vladimir Dergachev, Nir Osherov, Itai Benhar

US Provisional Patent Application 62/204.502, 2015 Filed 13 August 2015

2. “Alpha-hydrogen substituted nitroxyls and derivatives thereof as catalysts”

Alex M. Szpilman and Michal Amar

PCT international Application, WO 2013118118 A1 20130815, 2013.

1. “Alfa-Hydrogen Substituted Nitroxyls as Catalysts”

Alex M. Szpilman and Michal Amar

US Patent Application 61/595.184, 2012.

Pre- and Postdoctoral papers

11. 50 years of Synthesis and Biological Evaluation of Amphotericin B Derivatives: A Review

Astrid A. Volmer, Alex M. Szpilman and Erick M. Carreira*

Natural Product Reports 2010, 27, 1329-1349.

Highlighted in: Cheminform

10. Synthesis and Biophysical Studies on 35-Deoxy-Amphotericin B Methyl Ester

Alex M. Szpilman, Damiano M. Cereghetti, Jeffrey M. Manthorpe, Nicholas R. Wurtz and Erick M. Carreira*

Chemistry a European Journal 2009, 15(29), 7117 – 7128

9. β-Glycosidation of Sterically Hindered Alcohols

Alex M. Szpilman and Erick M. Carreira*

Organic Letters 2009, 11(6), 1305-1307

Highlighted in: Cheminform

8. Synthesis and Biological Studies of 35-Deoxy-Amphotericin B Methyl Ester

Alex M. Szpilman, Jeffrey M. Manthorpe and Erick M. Carreira*,

Angewandte Chemie International Edition, 2008, 47(23), 4339-4342

Selected as a “HOT Paper”by the editors.

Highlighted in: Philip Kocienski, Arndt W. Schmidt Synfacts 2008, 12, 1245-1245.

7. Synthesis of 35-Deoxy Amphotericin B Methylester: A Strategy for Molecular Editing

Alex M. Szpilman, Damiano M. Cereghetti, Nicholas R. Wurtz, Jeffrey M. Manthorpe and Erick M. Carreira*,

Angewandte Chemie International Edition, 2008, 47(23), 4335-4338

Selected as a “HOT Paper”by the editors.

Highlighted in: Philip Kocienski, Arndt W. Schmidt Synfacts 2008, 12, 1245-1245.

6. Scalable Synthesis of a Mycosamine Donor. Overcoming Difficult Reactivity in Allose Systems

Jeffrey M. Manthorpe, Alex M. Szpilman and Erick M. Carreira*,

Synthesis 2005, (Special Issue in Honor of Prof. Steven Ley) 3380-3388

5. Total Syntheses of Yingzhaosu A and its C(14)-Epimer including the First Evaluation of their Antimalarial and Cytotoxic Activitities”

Alex M. Szpilman, Edward E. Korshin, Haim Rozenberg and Mario D. Bachi*,

Journal of Organic Chemistry, 2005, 70, 3618-3632

Highlighted in: Cheminform

4. A Short Synthesis and Biological Evaluation of Potent and Nontoxic Antimalarial Bridged Bicyclic β-Sulfonyl-Endoperoxides

Mario D. Bachi*, Edward E. Korshin, Roland Hoos, Alex M. Szpilman, J. N. Cumming, P. Ploypradith, S. J. Xie, Theresa A. Shapiro, and Gary H. Posner,

Journal of Medicinal Chemistry, 2003, 46, 2516-2533

3. An Efficient Synthesis of Bridged Bicyclic Peroxides Structurally related to Antimalarial Yingzhaosu A based on a Radical Co-Oxygenation of Thiols and Monoterpenes

Edward E. Korshin, Roland Hoos, Alex M. Szpilman, Leonid Konstantinovski, Gary H. Posner and Mario D. Bachi*,

Tetrahedron, 2002, 58, 2449-2469

Highlighted in: Cheminform

2. The Iron(II)-Induced Cleavage of ß-Sulfonyl Endoperoxides. Evidence for the Generation of Potentially Cytotoxic Carbocations

Alex M. Szpilman, Edward E. Korshin, Roland Hoos, Gary H. Posner and Mario D. Bachi*,

Journal of Organic Chemistry, 2001, 66, 6531-6540

Highlighted in: Cheminform

1. The Synthesis and Reactions of Antimalarial Endoperoxides

Mario D. Bachi*, Edward E. Korshin, Roland Hoos and Alex M. Szpilman

Journal of Heterocyclic Chemistry, 2000, 37, 639-646

Highlighted in: Cheminform