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35. TBA

Lenin Kumar and Alex M. Szpilman*

Book Chapter, 2020, In review,

Publication 21.jpg

21. Design Concept for α-Hydrogen Substituted Nitroxyl Radicals

Michal Amar, Sukanta Bar, Mark A. Iron, Hila Toledo, Boris Tumanskii, Linda J. W. Shimon, Mark Botoshansky, Natalia Fridman and Alex M. Szpilman*   

Nature Communications, 2015, 6, 6070

​​​​​​​​​​​For the Technion's Press release in English see Click Here
For the Technion's Press release in Hebrew see Click Here
To read coverage of our work in the Jerusalem Post see Here

For coverage of our work at diplomacy.co.il Click Here
For coverage of our work in the Hebrew language media Click Here, Here, Here, Here, and Here

​​​Patents

3. “Amphotericin B Derivatives”

Alex M. Szpilman, Vladimir Dergachev, Nir Osherov, Itai Benhar

US Provisional Patent Application  62/204.502, 2015 Filed 13 August 2015

 

2. “Alpha-hydrogen substituted nitroxyls and derivatives thereof as catalysts”

Alex M. Szpilman and Michal Amar

PCT international Application, WO 2013118118 A1 20130815, 2013.

 

1. “Alfa-Hydrogen Substituted Nitroxyls as Catalysts”

Alex M. Szpilman and Michal Amar

US Patent Application 61/595.184, 2012.

Pre- and Postdoctoral papers

11. 50 years of Synthesis and Biological Evaluation of Amphotericin B Derivatives: A Review

Astrid A. Volmer, Alex M. Szpilman and Erick M. Carreira*

Natural Product Reports 2010, 27, 1329-1349.

Highlighted in: Cheminform

10. Synthesis and Biophysical Studies on 35-Deoxy-Amphotericin B Methyl Ester

Alex M. Szpilman, Damiano M. Cereghetti, Jeffrey M. Manthorpe, Nicholas R. Wurtz and Erick M. Carreira*

Chemistry a European Journal 2009, 15(29), 7117 – 7128

9. β-Glycosidation of Sterically Hindered Alcohols

Alex M. Szpilman and Erick M. Carreira*

Organic Letters 2009, 11(6), 1305-1307

 

Highlighted in: Cheminform

 

8. Synthesis and Biological Studies of 35-Deoxy-Amphotericin B Methyl Ester

Alex M. Szpilman, Jeffrey M. Manthorpe and Erick M. Carreira*,

Angewandte Chemie International Edition, 2008, 47(23), 4339-4342

 

Selected as a “HOT Paper”by the editors.

Highlighted in: Philip Kocienski, Arndt W. Schmidt Synfacts 2008, 12, 1245-1245.

7. Synthesis of 35-Deoxy Amphotericin B Methylester: A Strategy for Molecular Editing

Alex M. Szpilman, Damiano M. Cereghetti, Nicholas R. Wurtz, Jeffrey M. Manthorpe and Erick M. Carreira*,

Angewandte Chemie International Edition, 2008, 47(23), 4335-4338

 

Selected as a “HOT Paper”by the editors.

Highlighted in: Philip Kocienski, Arndt W. Schmidt Synfacts 2008, 12, 1245-1245.

​​​​​​​​6. Scalable Synthesis of a Mycosamine Donor. Overcoming Difficult Reactivity in Allose Systems

Jeffrey M. Manthorpe, Alex M. Szpilman and Erick M. Carreira*,

Synthesis 2005, (Special Issue in Honor of Prof. Steven Ley) 3380-3388

5. Total Syntheses of Yingzhaosu A and its C(14)-Epimer including the First Evaluation of their Antimalarial and Cytotoxic Activitities”

Alex M. Szpilman, Edward E. Korshin, Haim Rozenberg and Mario D. Bachi*,

Journal of Organic Chemistry, 2005, 70, 3618-3632

 

Highlighted in: Cheminform

4. A Short Synthesis and Biological Evaluation of Potent and Nontoxic Antimalarial Bridged Bicyclic β-Sulfonyl-Endoperoxides

Mario D. Bachi*, Edward E. Korshin, Roland Hoos, Alex M. Szpilman, J. N. Cumming, P. Ploypradith, S. J. Xie, Theresa A. Shapiro, and Gary H. Posner,

Journal of Medicinal Chemistry, 2003, 46, 2516-2533

 

3. An Efficient Synthesis of Bridged Bicyclic Peroxides Structurally related to Antimalarial Yingzhaosu A based on a Radical Co-Oxygenation of Thiols and Monoterpenes

Edward E. Korshin, Roland Hoos, Alex M. Szpilman, Leonid Konstantinovski, Gary H. Posner and Mario D. Bachi*, 

Tetrahedron, 2002, 58, 2449-2469

 

Highlighted in: Cheminform

 

2. The Iron(II)-Induced Cleavage of ß-Sulfonyl Endoperoxides. Evidence for the Generation of Potentially Cytotoxic Carbocations

 

Alex M. Szpilman, Edward E. Korshin, Roland Hoos, Gary H. Posner and Mario D. Bachi*,

Journal of Organic Chemistry, 2001, 66, 6531-6540

Highlighted in: Cheminform

1. The Synthesis and Reactions of Antimalarial Endoperoxides

Mario D. Bachi*, Edward E. Korshin, Roland Hoos and Alex M. Szpilman 

Journal of Heterocyclic Chemistry, 2000, 37, 639-646

Highlighted in: Cheminform

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